【人物简介】

闫亚平，博士,教授，博士生导师。2002、2005、2008年分别在陕西师范大学获得生物学本科硕士和博士学位。后于2008年至2012年在美国托马斯杰弗逊大学神经内科系进行博士后科研训练。2012年9月至2016年12月任天津医科大学总医院、天津市神经病学研究所研究员，神经免疫实验室主任，入选天津市“千人计划”青年项目。2013年被遴选为天津医科大学博士研究生导师。2017年1月加入陕西师范大学西北濒危药材资源开发国家工程实验室。主要从事神经免疫和神经炎症性疾病领域的研究，兼任中华医学会细胞生物学委员会青年委员会委员,担任国家重点研发计划“干细胞及转化研究试点专项”、“蛋白质机器”及“精准医学研究”重点研发计划项目评审专家 获得的奖励和人才项目： 1. 天津市“千人计划”（青年项目）入选者，2013年，50万元。 2. 天津市三年引进千名海外高层次人才计划入选者，2013年，8万元。 3. 天津市西青区创新创业领军人才，2014年，300万元。 4. 天津市西青区凌奥杯创新创业大赛一等奖，2014年，10万元。 5. 天津市第二届创新创业大赛二等奖，2014年，10万元。 6. 中国第三届创新创业大赛生物医药行业赛优秀团队，2014年。 7. 中枢神经系统炎性脱髓鞘疾病的免疫学、诊断和治疗研究，天津市科学技术进步奖二等奖，天津市人民政府，第三完成人。

【研究方向】

神经免疫学、神经系统疾病的免疫机制与干预

【研究成果】

先后主持国家自然科学基金项目4项，参与国家重大基础研究计划项目1项，已在国际一流刊物上发表40余篇学术论文，论文被引1000余次。 申请的专利： 1.闫亚平，崔郎军，李科。一种特异检测成熟microRNA表达水平的定量检测方法及试剂盒，专利申请号：2016100495963； 2 闫亚平，张鑫，李科。一种基于环介导等温扩增技术检测三种肠病毒试剂盒及检测方法，专利申请号：2016108769088； 3. 闫亚平，张鑫，李科。抗万古霉素肠球菌的引物对及检测试剂盒和检测方法，专利申请号：201610876816X。

【科研项目】

主持的科研项目： 1. 国家自然科学基金面上项目，81571596，膜锚定补体调节蛋白CD59在视神经脊髓炎中枢神经系统特异性病灶形成中的作用研究，2016/01-2019/12，64.8万元。 2. 国家自然科学基金面上项目，81371372，少突胶质前体细胞特异性miR-124在中枢神经系统炎性脱髓鞘疾病中的作用机制研究，2014/01-2017/12，70万元。 3. 中央高校基本科研业务费创新团队项目，GK201701009，免疫炎症与脑血管疾病，2017/01-2019/12, 40万元。 4. 国家自然科学基金主任基金项目，81241144，Lingo-1-fc修饰的iPS-NSC移植治疗自身免疫性脑脊髓炎的作用机制研究，2013/01-2013/12，15万元，已结题。 5. 国家自然科学基金青年基金项目，81100888，星形胶质细胞IFN-γ-IFN-γR信号通路在EAE疾病发生中的作用机制研究，2012/01-2014/12，23万元，已结题。 参加的科研项目： 1. 国家重点基础研究计划(973)项目，2013CB966900，干细胞分化产生的免疫原性及免疫耐受诱导，2013/01-2017/12，2900万元，在研，课题骨干（个人经费58万元）。

【论文著作】

2016: 1. Chen C, Zhang Y, Qiakefu K, Zhang X, Han L, Hu W, Yan Y, Wang Z. Overexpression of tomato prosystemin (LePS) enhances pest resistance and the production of tanshinones in Salvia miltiorrhiza Bunge. Journal of Agricuture and Food Chemistry, 2016, PMID: 27690419. 2. Shi K#, Wang Z, Liu Y, Gong Y, Fu Y, Hao JW, Shi F-D, Yan Y*. CFHR1-Modified Neural Stem Cells Ameliorated Brain Injury in a Mouse Model of Neuromyelitis Optica Spectrum Disorders. Journal of Immunology, 2016, 197: 3471-3480. 3. Zhang CJ#, Gong Y, Zhu W, Qi Y, Yang CS, Fu Y, Chang G, Li Y, Shi S, Wood K, Ladha S, Shi FD, Liu Q, Yan Y*. Augmentation of circulating follicular helper T cells and their impact on autoreactive B cells in Myashenia Gravis. Journal of Immunology, 2016, 197: 2610-2617. 4. Yu JW#, Li YH, Song GB, Yu JZ, Liu CY, Liu JC, Zhang HF, Yang WF, Wang Q, Yan YP, Xiao BG, Ma CG*. Synergistic and superimposed effect of bone marrow-derived mesenchymal stem cells combined with fasudil in experimental autoimmune encephalomyelitis. J Mol Neurosci, 2016, 60(1): 71-81. 5. Li YH, Yu JW, Xi JY, Yu WB, Liu JC, Wang Q, Song LJ, Feng L, Yan YP, Zhang GX, Xiao BG, Ma CG. Fasudil enhances therapeutic efficacy of neural stem cells in the mouse model of MPTP-induced Parkinson’s disease. Molecular Neurobiology, 2016, PMID: 27590141. 6. Li S#, Yan Y, Jiao Y, Gao Z, Xia Y, Kong L, Yao Y, Tao Z, Song J, Yan Y, Zhang G, Yang J*. Neuroprotective effect of Osthole on neuron synapses in an Alzheimer’s disease cell model via upregulation of microRNA-9. J Mol Neurosci, 2016, 60 (1):71-81. 7. Li X#, Zhang Y#, Yan Y#, Ciric B, Ma CG, Chin J, Curtis M, Rostami A, Zhang GX*. LINGO-1-fc-transduced neural stem cells are effective therapy for chronic stage experimental autoimmune encephalomyelitis. Mol Neurobiol, 2016, PMID: 27344330. 8. Fu Y#, Yan Y, Qi Y, Yang L, Li T, Zhang N, Yu C, Su L, Zhang R, Shen Y, Lin S, Liu Q, Shao Z, Han Z, Shi FD*. Impact of autologous mesenchymal stem cell infusion on neuromyelitis optica spectrum disorder: a pilot, 2-year observation study. CNS Neurosci Ther, 2016, 22 (8): 677-685. 9. Li X#, Zhang Y#, Yan Y, Ciric B, Ma C-G Gran B, Curtis M, Rostami A, Zhang G-X*. Neural stem cells engineered to express three therapeutic factors mediate recovery from chronic stage CNS autoimmunity. Molecular Therapy, 2016. 24(8): 1456-1469. 10. Yan Y#*, Li Y, Fu Y, Yang L, Su L, Shi K, Li M, Liu Q, Borazanci A, Liu Y, He Y, Bennett JL, Vollmer TL, Shi FD*. Autoantibody to MOG suggests two distinct clinical subtypes of NMOSD. SciChinaLife Sci. 2016, 59(12):1270-1281. 2015: 11. Liu Y, Fu Y, Schoonheim MM, Zhang N, Fan M, Su L, Shen Y, Yan Y, Yang L, Wang Q, Zhang N, Yu C, Barkhof F, Shi FD. Structural MRI substrates of cognitive impairment in neuromyelitis optica. Neurology, 2015, 85: 1491-1499. 12. Li M#, Yan Y*. Experimental models of neuromyelitis optica: current status, challenges and future directions. Neurosci Bull, 2015, 31:735-744. 13. Li YJ#, Chang GQ, Liu Y, Gong Y, Yang C, Wood K, Shi FD, Fu Y*, Yan Y*. Fingolimod alters inflammatory mediators and vascular permeability in intracerebral hemorrhage. Neurosci Bull, 2015, 31:755-762. 14. Ding X#, Yan Y#, Li X#, Li K#, Ciric B, Yang J, Zhang Y, Wu S, Xu H, Chen W, Lovett-Racke AE, Zhang GX*, Rostami A*. Silencing IFN-γ binding/signaling in astrocytes versus microglia leads to opposite effects on central nervous system autoimmunity. J Immunol, 2015, 194: 4251-4264. (#, equal contribution). 15. Li YJ#, Zhang F, Qi Y, Chang GQ, Fu Y, Su L, Shen Y, Sun N, Borazanci A, Yang C, Shi FD, Yan Y*. Association of circulating follicular helper T cells with disease course of NMO spectrum disorders. J Neuroimmunol, 2015, 278: 239-46. 2014: 16. Fu Y#, Zhang N, Ren L, Yan Y, Sun N, Li YJ, Han W, Xue R, Liu Q, Hao J, Yu C, Shi FD*. Impact of an immune modulator fingolimod on acute ischemic stroke. Proc Natl Acad Sci U S A. 2014 , 111(51): 18315-20. 17. Kong XD#, Bai S, Chen X, Wei HJ, Jin WN, Li MS, Yan Y, Shi FD*. Alterations of natural killer cells in traumatic brain injury. Neurosci Bull. 2014, 30 (6): 903-12. 18. Fu Y#, Hao J, Zhang N, Ren L, Sun N, Li YJ, Yan Y, Huang D, Yu C, Shi FD*. Fingolimod for the treatment of intracerebral hemorrhage: a 2-arm proof-of-concept study. JAMA Neurol. 2014, 71(9):1092-101. 19. Kalantari T#, Karimi MH, Ciric B, Yan Y, Rostami A and Kamali-Sarvestani E*. Tolerogenic dendritic cells produced by lentiviral-mediated CD40- and IL-23p19- specific shRNA can ameliorate experimental autoimmune encephalomyelitis by suppressing Th17 cells. Clin Exp Immunol, 2014, 176(2): 180-189. 20. Zhang CJ#, Zhai H, Yan Y, Hao J, Li MS, Jin WN, Su N, Vollmer TL, Shi FD*. Glatiramer acetate ameliorates experimental autoimmune neuritis. Immunol Cell Biol. 2014, 92(2):164-9. 21. Yang J#, Yan Y#, Xia Y, Kang T, Li X, Ciric B, Xu H, Rostami A, Zhang GX*. Neurotrophin 3 Transduction Augments Remyelinating and Immunomodulatory Capacity of Neural Stem Cells. Mol Ther. 2014, 22 (2): 440-50. 2013: 22. Wu S#, Li K, Yan Y, Gran B, Han Y, Zhou F, Guan YT, Rostami A, Zhang GX*. Intranasal Delivery of Neural Stem Cells: A CNS-specific, Non-invasive Cell-based Therapy for Experimental Autoimmune Encephalomyelitis. J Clin Cell Immunol. 2013; 4(3). doi: 10.4172/2155-9899.1000142. 23. Zhang N#, Wen Q, Ren L, Liang W, Xia Y, Zhang X, Zhao D, Sun D, Hu Y, Hao H, Yan Y, Zhang G, Yang J, Kang T*. Neuroprotective effect of arctigenin via upregulation of P-CREB in mouse primary neurons and human SH-SY5Y neuroblastoma cells. Int J Mol Sci. 2013;14(9):18657-69. 24. Yan Y#, Li Z, Zhang GX, Williams MS, Carey GB, Zhang J, Rostami A, Xu H*. Anti-MS4a4B treatment abrogates MS4a4B-mediated protection in T cells and ameliorates experimental autoimmune encephalomyelitis. Apoptosis. 2013;18(9):1106-19. 25. Li Y#, Wang Y, Yu L, Sun C, Cheng D, Yu S*, Wang Q, Yan Y, Kang C, Jin S, An T, Shi C, Xu J, Wei C, Liu J, Sun J, Wen Y, Zhao S, Kong Y. miR-146b-5p inhibits glioma migration and invasion by targeting MMP16. Cancer Lett. 2013; 339(2):260-9. 26. Zhang Y#, Yan YP, Wu YC, Hua WP, Chen C, Ge Q, Wang ZZ*. Pathway engineering for phenolic acid accumulations in Salvia miltiorrhiza by combinational genetic manipulation. MetabEng.2013; 21C:71-80. 27. Wang Y#, Li Y, Sun J, Wang Q, Sun C, Yan Y, Yu L, Cheng D, An T, Shi C, Xu J, Wei C, Liu J, Wen Y, Zhao S, Li H, Zhang H, Xu H, Yu S*. Tumor-suppressive effects of miR-29c on gliomas. Neuroreport. 2013; 24(12):637-45. 28. Li Z#, Li K, Zhu L, Kan Q, Yan Y, Kumar P, Xu H, Rostami A, Zhang GX*. Inhibitory effect of IL-17 on neural stem cell proliferation and neural cell differentiation. BMC Immunol. 2013; 14:20. 2012: 29. Zhang N#, Kang T, Xia Y, Wen Q, Zhang X, Li H, Hu Y, Hao H, Zhao D, Sun D, Yan Y, Zhang GX, Yang J*. Effects of salvianolic acid B on survival, self-renewal and neuronal differentiation of bone marrow derived neural stem cells. Eur J Pharmacol, 2012, 697 (1-3): 32-39. 30. Zhou F#, Ciric B, Li H, Yan Y, Cullimore M., Safavi F., Zhang G.X., and Rostami AM*. IL-10 deficiency blocks the ability of LPS to regulate expression of tolerance-related molecules on dendritic cells. Eur. J. Immunol. 2012, 42 (6): 1449-1458. 31. Yan Y#, Zhang G-X, Williams MS, Carey GB, Rostami AM, and Xu H*. TCR stimulation upregulates MS4a4B expression through induction of AP-1 transcription factor during T cell activation. Molecular Immunology, 2012, 52(2):71-8. 32. Yang J#, Yan Y#, Ciric B, Yu S, Ciric B, Guan Y, Xu H, Rostami AM, Zhang GX*. Acceleraated and enhanced effect of CCR5-transducedbone marrow neural stem cells on autoimmune encephalomyelitis. Acta Neuropathologica, 2012, 124(4):491-503. 33. Yu D#, Corbett B, Yan Y, Zhang GX, Reinhart P, Cho SJ, Chin J*. Early cerebrovascular inflammation in a transgenic mouse model of Alzheimer's disease. Neurobiol Aging, 2012, 33(12):2942-2947. 34. Wang ZJ#, Cui LJ, Chen C, Liu XJ, Yan Y, and Wang Z*. Downregulation of Cinnamoyl CoA Reductase affects Lignin and Phenolic Acids Biosynthesis in Salvia miltiorrhiza Bunge. Plant Molecular Biology Reporter，2012, 30 (5): 1229-1236. 35. Yan Y#, Ding X#, Li K#, Ciric B., Xu H., Gran B., Rostami A., Zhang G. X*. CNS- specific therapy for ongoing EAE by silencing IL-17 pathway in astrocytes. Molecular Therapy, 2012, 20(7):1338-48. 2011: 36. El-Behi M#, Ciric B#, Dai H, Yan Y, Cullimore M, Safavi F, Zhang GX, Dittel BN, Rostami A*. The encephalitogenicity of Th17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat Immunol. 2011, 12 (6): 568-575. 2010 : 37. Yang J#, Yan Y#, Ciric B, Yu S, Guan Y, Xu H, Rostami AM, Zhang GX*. Evaluation of bone marrow- and brain-derived neural stem cells in therapy of central nervous system autoimmunity. Am. J. Pathol. 2010, 177:1989-2001. 38. Yan Y#, Zhang G X, Cric B, Rostami AM, Xu H*. IDO upregulates Treg cells via tryptophan catabolite and suppresses encephalitogenic T cell responces in EAE. J. Immunol. 2010, 185:5953-61. 39. Xu H#*, Yan Y, Fitzgerald DC, Zhang GX, Rostami AM*. MS4a4B, a CD20 homologue in T cell, inhibits T cell propagation by modulation of cell cycle. PloS One, 2010, Nov 1; 5(11):e13780. 40. Zhang Y#, Yan Y, Wang Z*. The Arabidopsis PAP1 transcription factor plays an important role in the enrichment of phenolic acids in Salvia miltiorrhiza. J Agr Food Chem, 2010, 58, 12168-12175. 41. Yan Y#, Wang Z*, Tian W, Dong Z, Spencer SF. Generation and analysis of expressed sequence tags from the medicinal plant Salvia miltiorrhiza. SciChinaLife Sci, 2010, 53 (2): 273-285. 2008: 42. Yan Y#, Wang Z*. Genetic transformation of the medicinal plant Salvia miltiorrhiza by Agrobacterium tumefaciens-mediated method. Plant Cell, Tissue and Organ Culture, 2007, 88: 175-184.