【人物简介】

　　马小魁，副教授，男，博士，硕士生导师。曾先后在山东大学微生物学系微生物工程专业获理学学士，第四军医大学获细胞生物学细胞工程方向专业博士学位。曾先后主持和参与过多项国家和省自然基金及攻关课题，省农办技术推广项目多项，主持过多家生物技术企业的生产技术改进和我校微生物工程实验室的改造和建设，有丰富的微生物生产技术指导经验和解决相关发酵工程技术难题的经历，获得授权国家发明专利两项，正在申请一项。曾在BMC cell biology、Chinese Journal of Catalysis等杂志发表过研究性论文多篇。目前主持陕西省省科技攻关课题一项，企业合作项目一项，参与973、国科金、西安市科技攻关项目各一项。

【研究方向】

1、 微生物技术药物。 2、 应用生物毒理学与环境友好微生物。

【研究成果】

【科研项目】

【论文著作】

　　1. Ma XK, Wang L, Li Y, Yang XM, Zhao P, Tang H, Zhu P, Li L, Chen ZN. HAb18G/CD147 cell-cell contacts confer resistance of a HEK293 subpopulation to anoikis in an E-cadherin-dependent manner.BMC Cell Biol. 2010 Apr 17;11(1):27. 　　2. Zhao P, Zhang W, Tang J, Ma XK, Dai JY, Li Y, Jiang JL, Zhang SH, Chen ZN. Annexin II promotes invasion and migration of human hepatocellular carcinoma cells in vitro via its interaction with HAb18G/CD147.Cancer Sci. 2010 Feb;101(2):387-95. Epub 2009 Nov 2. 　　3. Wang L, Wang CH, Jia JF, Ma XK, Li Y, Zhu HB, Tang H, Chen ZN, Zhu P. Contribution of cyclophilin A to the regulation of inflammatory processes in rheumatoid arthritis.J Clin Immunol. 2010 Jan;30(1):24-33. Epub 2009 Sep 30. 　　4. MA Xiao-kui; WANG Zhe zhi; CHEN Wuling.Asymmetric Reduction of Ethyl 4-Chloro-3-Oxobutanoate to Ethyl 4-Chloro3-Hydroxybutanoate Directly Catalyzed by Yeast Fermentation Broth. Chinese Journal of Catalysis. Vol. 27 No. 4:314-318. 　　5. MA Xiao-Kui.Optimization for the asymmetric synthesis of (S)-ethyl 4-chloro-3- hydroxybutanoate directly catalyzed by yeast fermentation broth. J Fourth Mil Med Univ. 2006; 27 (17) 1555-1558. 　　6. MA Xiao-kui.Advance in Synthesis of Chiral Drug by Transformation with Microbial Enzyme.JOURNAL OF MICROBIOLOGY Sept . 2006 Vol. 26 No. 5:71-74. 　　7. Cao Jun-feng; Yao Pei-xin; Ma Xiao-kui.The breeding of saccharomycete on resist high alcohol concentration in the fermentational sweet sorghum juice. Acta Botanica Boreali-occidentalia Sinica. 2001, 21 (5) : 1009—1012. 　　8. Yao Pei xin,Ma Xiao kui. Online exploration of thermophilic acidophilic bacteria in fruit juice concentrate manufacturers. The Beverage Industry. 2001.Vol14 　No13:42-48. 　　9. Ma xiao kui,Yao pei xing.The development of propionic acid production by fermentation.MICROBIOLOGY.1996,26,6:443-446. 　　10. Ma xiao kui,chen zhinan. The suspension-adapted-adherent mammalian cell HEK293ar acquisition and its survival mechanism study. 11~(th) Chinese Conference on Cell Biology & Xi an International Conference on Cell Biology 2009.