肖书奇
肖书奇
性      别: 职      称: 教育,高等学校教师,副教授
籍      贯: 陕西省 西安市 现 居 地: 河南省 开封市
毕业院校: 中山大学 专      业: 生物技术
查看更多个人信息
出生年月: 1979-01 工作单位: 西北农林科技大学动物医学院
邮       箱: xiaoshuqi@nwsuaf.edu.cn 联系电话:
学       历: 博士

【人物简介】

  肖书奇,1979年1月出生于河南省尉氏县,西北农林科技大学动物医学院副教授,硕士生导师。2010年6月于中山大学生物技术专业获博士学位,2007年7月于吉林大学畜牧兽医学院获硕士学位,2003年7月于河南科技学院动物科学学院获学士学位。2010年7月至2012年6月在中山大学生命科学学院有害生物控制与资源利用国家重点实验室进行博士后研究。中国免疫学会高级会员、中国畜牧兽医学会动物遗传育种学分会会员。   主要研究方向为动物分子病毒免疫学与功能基因组学。发表论文30余篇,其中PLoS One、BMC Genomics、Virology Journal等SCI论文近20篇,多篇论文获中国畜牧兽医学会、中国农业生物技术学会等“优秀论文奖”。

【研究方向】

1.病毒与宿主细胞相互作用研究。 2.动物抗病毒制剂及新型疫苗与免疫增强剂开发。 3.动物转基因抗病育种研究

【研究成果】

【科研项目】

  (1)国家自然科学基金:猪ncRNA在PRRSV强弱毒株感染中的差异调控作用及遗传多态性与PRRS易感相关性研究,31101690,23万,2012.01-2014.12.   (2)中国博士后科学基金:猪DDAH基因的表达调控及遗传多态性与PRRS易感性的关联研究,20100480823,3万,2011.01-2012.12.   (3)广东省自然科学基金:猪HMOX基因对PRRS抗病性影响的遗传基础研究,S2011040001671,3万,2011.10-2013.10.   (4)有害生物控制与资源利用国家重点实验室开放课题:猪肺泡巨噬细胞编码的miRNAs对蓝耳病病毒感染的调控作用及分子机制,SKLBC12K13,5万,2012.10-2014.10.   (5)西北农林科技大学引进人才科研启动项目:表观遗传学调控在PRRSV感染中的作用,Z111021201,30万,2012.9-2015.9.   2、主要参与的科研项目:   (1)农业部科研项目:华南区域地方猪种单核苷酸多态性(SNP)研究,2011330004109957,2011.1-2011.12.(排名第三,主要完成人   (2)教育部高校基本科研业务费青年教师培育项目:计算机辅助设计靶向猪基因组的人工锌指酶,2011330003161075,2011.7-2013.13.(排名第三)   (3)国家科技支撑计划:中国特色联合育种体系构建,2012330004107992,2012.01.01-2015.12.31(排名第三)   (4)广东省农业厅项目:生猪创新团队岗位专家建设任务,2010330004202125,2010.1-2011.11.(排名第五)   (5)广东省科技厅科技计划项目:广东省生猪改良繁育工程技术研究开发中心,2010330004202061,2011.1-2013.12.(排名第六)   (6)吉林省科技计划项目:吉林地方猪种繁殖、生长与肉质性状基因标记的研究,2005.1-2007.12.(排名第五)   (7)全国畜牧总站合作项目:地方猪种(太湖流域、华南区域)单核苷酸多态性(SNP)分析样本采集,2011330007102011,2011.1-2011.9.(排名第二,主要完成)   (8)企业合作项目:规模化猪场蓝耳病新型预警防控措施的研究与开发,2011330007103002,2011.1-2011.12.(排名第四)

【论文著作】

  1.Shuqi Xiao, Jianyu Jia, Delin Mo, Qiwei Wang, Limei Qin, Zuyong He, Xiao Zhao, Yuankai Huang, Anning Li, Jingwei Yu, Yuna Niu, Xiaohong Liu, Yaosheng Chen. Understanding PRRSV infection in porcine lung based on genome-wide transcriptome response identified by deep sequencing. PLoS ONE, 2010, 5(6): e11377.   2.Shuqi Xiao, Delin Mo, Qiwei Wang, Jianyu Jia, Limei Qin, Xiangchun Yu, Yuna Niu, Xiao Zhao, Xiaohong Liu,Yaosheng Chen. Aberrant immune response in infection of pigs with the highly virulent PRRSV (H-PRRSV) identified by high-throughput digital gene expression tag profiling. BMC Genomics, 2010,11(1):544.   3.Shuqi Xiao, Qiwei Wang, Jianyu Jia, Peiqing Cong, Delin Mo, Xiangchun Yu, Limei Qin, Anning Li, Yuna Niu, Kongju Zhu, Xiaoying Wang, Xiaohong Liu, Yaosheng Chen. Proteome changes of lungs artificially infected with H-PRRSV and N-PRRSV by Two-dimensional fluorescence difference gel electrophoresis. Virology Journal, 2010, 7(1):107.   4.Shuqi Xiao, Qiwei Wang, Jintao Gao, Liangliang Wang, Zuyong He, Delin Mo, Xiaohong Liu, Yaosheng Chen. Inhibition of highly pathogenic PRRSV replication in MARC-145 cells by artificial microRNAs. Virology Journal, 2011, 8(1):491.   5.Shuqi Xiao, Shuang Li, Jiabao Zhang, Shumin Zhang, Lisheng Dai, Yonghua Bao, Ning Jiang, Yan Gao, Zhongli Zhao, Delin Mo, Yaosheng, Chen, Zhihui Zhao. Cloning and characterization of class 1 and class 2 insulin-like growth factor-I mRNA in Songliao black pig. Molecular Biology Reports, 2009, 36(2):415-21.   6.Yonghua Bao, Yongchen Guo, Shuqi Xiao, Zhihui Zhao. Molecular characterization of the VH repertoire in Canis familiaris. Veterinary Immunology and Immunopathology, 2010, 137(1-2):64-75.   7.Lisheng Dai, Zhihui Zhao, Ruifeng Zhao, Shuqi Xiao, Hao Jiang, Xufeng Yue, Xichun Li, Yan Gao, Jifeng Liu, Jiabao Zhang. Effects of novel single nucleotide polymorphisms of the FSH beta-subunit gene on semen quality and fertility in bulls. Animal Reproduction Science, 2009, 114(1-3):14-22.   8.Xiao Zhao, Delin Mo, Anning Li, Wen Gong, Shuqi Xiao, Yue Zhang, Limei Qin, Yuna Niu, Yunxue Guo, Xiaohong Liu, Peiqing Cong, Zuyong He, Chong Wang, Jiaqi Li, Yaosheng Chen. Comparative analyses by deep-sequencing of transcriptome during skeletal muscle development between two pig breeds differing in muscle growth rate. PLoS ONE, 2011, 6(5):e19774.   9.Zigong Wei, Qiang Fu, Yaosheng Chen, Peiqing Cong, Shuqi Xiao, Delin Mo, Zuyong He, Xiaohong Liu. The capsule of Streptococcus equi ssp. zooepidemicus is a target for attenuation in vaccine development. Vaccine. 2012,30(31):4670-5.   10.Limei Qin, Yaosheng Chen, Yuna Niu, Weiquan Chen, Qiwei Wang, Shuqi Xiao, Anning Li, Ying Xie, Jing Li, Xiao Zhao, Zuyong He, Delin Mo. A deep investigation into the adipogenesis mechanism: Profile of microRNAs regulating adipogenesis by modulating the canonical Wnt/beta-catenin signaling pathway. BMC Genomics, 2010, 11(1):320.   11.Yuna Niu, Delin Mo, Limei Qin, Chong Wang, Anning Li, Xiao Zhao, Xiaoying Wang, Shuqi Xiao, Qiwei Wang, Ying Xie, Zuyong He, Peiqing Cong, Yaosheng Chen. Lipopolysaccharide -induced miR-1224 negatively regulates tumor necrosis factor - gene expression by modulating Sp1. Immunology, 2011, 133(1):8-20.   12.Weiquan Chen, Yaosheng Chen, Limei Qin, Anning Li, Xiao Zhao, Xiaoying Wang, Shuqi Xiao, Delin Mo, Transcription factor Sp1 is essential for the regulation of the porcine Caveolin-1 gene. DNA and Cell Biology, 2011, 30(7):491-7.   13.Yan Gao, Yonghong Zhang, Hao Jiang, Shuqi Xiao, Shuai Wang, Jiabao Zhang. Detection of differentially expressed genes in the longissimus dorsi of Northeastern Indigenous and Large White pigs. Genetics and Molecular Research 2011, 10 (2): 779-791.   14.Yan Gao, Yonghong Zhang, Shumin Zhang, Fujuan Li, Shuai Wang, Lisheng Dai, Hao Jiang, Shuqi Xiao, Dianfeng Liu, Boxing Sun, Zhihui Zhao, Jiabao Bao Zhang. Association of A-FABP gene polymorphism in intron 1 with meat quality traits in Junmu No. 1 white swine. Gene, 2011, 487(2):170-173.   15.Xiao Zhao, Delin Mo, Anning Li, Wen Gong, Yue Zhang, Weiwei Qian, Weiquan Chen, Shuqi Xiao, Ying Xie, Yaosheng Chen. Characterization and transcriptional regulation analysis of the porcine PAQR6 gene. DNA and Cell Biology, 2011, 30(11):947-54.   16.Yunxue Guo, Delin Mo, Yue Zhang, Yun Zhang, Peiqing Cong, Shuqi Xiao, Zuyong He, Xiaohong Liu, Yaosheng Chen. MicroRNAome Comparison between Intramuscular and Subcutaneous Vascular Stem Cell Adipogenesis. PLoS ONE, 2012, 7(9):e45410.   17.Zigong Wei, Qiang Fu, Yaosheng Chen, Peiqing Cong, Shuqi Xiao, Delin Mo, Zhuyong He, Xiaohong Liu, Identification of Streptococcus equi ssp. zooepidemicus surface associated proteins by enzymatic shaving, Veterinary Microbiology, 2012, 159:519–525.   18.肖书奇,张树敏,张嘉保,李爽,高妍,姜宁,戴立胜,赵中利,赵志辉. 松辽黑猪IGF-I基因SNP与生长和胴体性状的关联性.中国兽医学报,2008,28(6):724-728.

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