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周乐
周乐
性      别： 男 职      称： 教育,高等学校教师,教授
籍      贯： 陕西省 咸阳市 现 居 地： 陕西省 渭南市
毕业院校： 西北农林科技大学 专      业： 动物医学
查看更多个人信息
出生年月： 1965年 工作单位： 西北农林科技大学理学院
邮       箱： betterzl@163.com 联系电话：
学       历： 博士

【人物简介】

　　周乐，男，1965年出生于陕西蒲城县， 现为西北农林科技大学理学院有机化学专业教授。教育部高等学校化学与化工学科教学指导委员会会员。教育部第三届霍英东基金优秀教师奖获得者。 　　工作学习简历 　　2010.12-今 教授， 西北农林科技大学理学院 　　2005.12-2007.1 访问学者，美国宾夕法尼亚洲立大学化学系 　　1996.7-2001.12 副教授， 西北农林科技大学（原西北农业大学）基础科学系 　　1999.9-2005.1 副主任，西北农林科技大学测试中心 　　1994.9-1998.7 博士，西北农林科技大学（原西北农业大学）动物医学系 　　1994.12-1996.7 讲师，西北农林科技大学（原西北农业大学）基础科学系 　　1990.12-1994.12,助教，西北农林科技大学（原西北农业大学）基础科学系 　　1987.9-1990.12 硕士，西北农林科技大学（原西北农业大学）基础科学系 　　1983.9-1987.6 学士，西北大学化学系

【研究方向】

主要从事有机合成、天然产物化学和药物化学的研究。近年来的研究重点是天然活性化合物的构效关系、天然活性化合物类似物的分子设计、合成及其药理活性、植物化学成分及其药理活性成分和有机不对称氢化反应。在药物研发方面，着重于动物、植物和人的抗菌药物、抗病毒药物、抗癌药物和抗虫药物。

【研究成果】

【科研项目】

【论文著作】

　　已发表学术论文95篇，其中SCI收录22篇，申报国家发明专利3项，主编（参编）专著6部。近年来发表的主要论文： 　　1. Jian Yang, Yan-hong Zhang, Fang Miao, Le Zhou, Wei Sun. Two new bufadienolides from the rhizomes of Helleborus thibetanus Franch. Fitoterapia, 2010, 81. http://dx.doi.org/10.1016/j.fitote.2010.03.009. 　　2. Fang Miao, Bao-Fu Qin, Li-Zhen Yang, Xin-Juan Yang and Le Zhou. （E）-3-[2,5-Dioxo-3-（propan-2-ylidene）pyrrolidin-1-yl]acrylic acid, Acta Crystallographica Section E, Structure Reports Online, 2010, E66, o634. 　　3. Fang Miao, Xin-juan Yang, Le Zhou, Hai-jun Hu, Feng Zheng, Xu-dong Ding, Dong-mei Sun, Chun-dong Zhou, Wei Sun. Structural modification of sanguinarine and chelerythrine and their antibacterial activity, Natural Product Research, 2010, 24. 　　4. Yang Xin-juan, Zhou Le, Miao Fang, Wang Xin, Sun Wei, Geng Hui-ling. Isolation and identification of alkaloids from Macleaya microcarpa（Maxim） Fedde, Acta Bot. Boreal.–Occident. Sin., 2009, 30（2）： 0405-0411. 　　5. Xianfeng Sun, Wei Li, Guohua Hou, Le Zhou, and Xumu Zhang. Axial Chirality Control by 2,4-Pentanediol for the Alternative Synthesis of C3-TunePhos Chiral Diphosphine Ligands and Their Applications in Highly Enantioselective Ruthenium-Catalyzed Hydrogenation of β-Keto Esters, Adv. Synth. Catal. 2009, 351, 2553-2557. DOI: 10.1002/adsc.200900589 　　6. Sun Xianfeng, Li Wei, Zhou Le, Zhang Xumu. Matching and Mismatching Effects of Hybrid Chiral Biaxial Bisphosphine Ligands in Enantioselective Hydrogenation of Ketoesters. Chemistry--A European Journal, 2009, 15（30）： 7302-7305. 　　7. Geng Huiling, Zhang Weicheng, Chen Jian, Hou Guohua, Zhou Le, Zou Yaping, Wu Wenjun, Zhang Xumu. Rhodium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of β-Ketoenamides: Efficient Access to anti 1,3-Amino Alcohols. Angewandte Chemie, International Edition, 2009, 48（33）： 6052-6054. 　　8. Le Zhou, Chao Lv, Gai-Ling Wang, Hui-Ling Geng, Jian-Wu Yang, Peng Chen. Syntheses of R-β-rutinosides by rutin-degrading reaction, Journal of Asian natural product research, 2009, 11（1）： 18-23. 　　9. Li, Wei; Sun, Xianfeng; Zhou, Le; Hou, Guohua; Yu, Shichao; Zhang, Xumu. Highly Efficient and Highly Enantioselective Asymmetric Hydrogenation of Ketones with TunesPhos / 1,2-Diamine-Ruthenium（II） Complexes. J. Org. Chem., 2009, 74 （3）： 1397-1399. 　　10. Le Zhou, Xin-Ke Li, Fang Miao, Ming-Li Yang, Xin-Juan Yang, Wei Sun, Jian Yang. Further studies on the chemical constituents of Chinese folk medicine Gentiana apiata N.E.Br., Journal of Asian natural product research, 2009,11（4）： 345-351. 　　11. Ma, Yanni, Zhou Le, Deng Dongsheng, Ji Baoming. 4,4',6,6'-Tetramethyl-2,2'-bipyrimidine hexahydrate. Acta Crystallographica, Section E: Structure Reports Online, 2009, E65（4）， o848-o849. 　　12Sun X F, Zhou L, Li W, Zhang X M. Convenient Divergent Strategy for the Synthesis of TunePhos-Type Chiral Diphosphine Ligands and Their Applications in Highly Enantioselective Ru-Catalyzed Hydrogenations. Journal of Organic Chemistry, 2008, 73（3）： 1143-1146. 　　13. Hu X Y, Luo Y G, Chen X Z, Zhou L , Zhang G L. Chemical Constituents of Nouelia insignis Franch, Journal of Asian natural product research, 2008, 10（2）： 125-131. （IF 0.651） 　　14. Hong-Ji Ma, Chen Xu, Zhi-Qiang Wang, Le Zhou* and Bao-Ming Ji. 2,4,6-Trimethyl-1,3,5-tris （morpholinomethyl） benzene, Acta Cryst. 2008, E64, o993 （IF 0.367） 　　15. Sun X F, Zhou L, Zhang X M. Rh-Catalyzed Highly Enantioselective Synthesis of β-methylcinnamic Acids, Angewandte Chemie International Edition, 2007, 46（15）： 2623-2626. 　　16. HU X Y, Wu X W, Mei N, Zhou L*. Structure Characteristics of A Sesquiterpene Lactone from Nouelia insignis Franch by 2D NMR, Chinese Journal of Magnetic Resonance, 2007, 24（2）： 141-145. 　　17. 周乐， 王宁， 苗芳， 赵海双， 田鹏。 秦岭龙胆的化学成分。 有机化学， 2004, 24（10）： 1249-1252.

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