【人物简介】

　　王超展，男，博士，副教授，硕士生导师。生于1977年7月，陕西礼泉人。1995年考入西北大学化学系本硕连读班，2001年7月获理学硕士学位。2005年1月在西北大学分析化学专业获理学博士学位。2005年2月留校任教，先后承担本系本科生《环境化学导论》、《综合化学实验》、《大一化学实验》、《液相色谱及其在生物医药中的应用》，研究生《生物大分子的高效液相色谱实验》以及生命科学院《分析化学》和《分析化学实验》等课程的主讲工作。2008年10月至今在芬兰奥卢大学生物化学系做博士后，从事神经系统中膜蛋白的表达、纯化、结构解析以及与大分子和小分子配体相互作用的研究。

【研究方向】

生物分离与分析、色谱分析。

【研究成果】

【科研项目】

　　陕西省教育厅重点科研计划项目“重组人粒细胞集落刺激因子的基因工程中试生产”(05JS61)，30万，项目主持人 　　国家自然科学基金资助项目“新型温敏疏水色谱及其对蛋白质的复性并同时纯化”(批准号：20705028)，18万，项目主持人。

【论文著作】

　　1. Chaozhan Wang,Xiudu Geng,Dawei Wang,Bo Tian,Purification of recombinant bovine normal prion protein PrP(104-242)by HPHIC,Journal of chromatography B,2004,806:185-190 　　2. 王超展,耿信笃,蛋白质的排阻色谱复性的新进展,中国生物工程杂志,2004,24(7):45-49 　　3. 龚波林,王超展,王骊丽,耿信笃,以单分散交联聚甲基丙烯酸环氧丙酯树脂为基质的亲水性排阻色谱固定相的合成及其在生物大分子分离中的应用,分析化学,2004,32(5):565-568 　　4. Bolin Gong,Lili Wang,Chaozhan Wang,Xindu Geng,Preparation of hydrophobic interaction chromatographic packings based on monodisperse poly(glycidylmethacrylate-co-ethylenedimethacrylate)beads and their application,Journal of Chromatography A,2004,1022:33-39 　　5. Chaozhan Wang,Jiangfeng Liu,Xindu Geng,Refolding with simultaneous purification of recombinant human granulocyte colony-stimulating factor from Escherichia coli using strong anion exchange chromatography,Chinese Chemical letters,2005,16(3):389-392 　　6. 王超展,耿信笃,箭叶淫羊藿中5种黄酮类化合物的反相色谱分离制备,分析化学,2005,33(1):106-108 　　7. Wang Chaozhan,Wang Lili,Geng Xindu,Renaturation of recombinant human granulocyte colony-stimulating factor produced from Escherichia coli using size exclusion chromatography,Journal of Liquid Chromatography and Related Techniques,2006,29:203-217 　　8. Chaozhan Wang,Lili Wang,Xindu Geng,Refolding of recombinant human granulocyte colony-stimulating factor expressed by E.coli,BioProcess International,2006,4(5):48-54 　　9. 王超展，王骊丽，耿信笃，重组人粒细胞集落刺激因子的疏水色谱复性并同时纯化，南昌大学学报(理科版)，2006,30卷专辑:497-498 　　10. 王丽霞，王超展，耿信笃，淫羊藿属药材反相高效液相色谱指纹图谱及质量评估研究，化学学报，2006,64(6):551~555 　　11. Liu Jiahua,Wang Chaozhan,Geng Xindu.A new protocol for solubilization,refolding and purification of recombinant human granulocyte colony-stimulating facteo in inclusion bodies.Chinese Chemical Letters,2006,17(6):799-802 12. Lili Wang,Chaozhan Wang,Xindu Geng,Refolding with simultaneous purification of recombinant human stem cell factor expressed in Escherichia coli by high performance hydrophobic interaction chromatography,Biotechnology Letter,2006,28(7):993-997 　　13. Xindu Geng,Chaozhan Wang,Protein folding liquid chromatography and its recent developments,Journal of Chromatography B,2007,849:69-80 　　14. Dan Wu,Chaozhan Wang,Xindu Geng,An approach for increasing the mass recovery of proteins derived from inclusion bodies in biotechnology,Biotechnology Progress,2007,23(2):407-412 　　15. 吴丹，王超展，耿信笃，蛋白折叠液相色谱法中流动相对重组人干扰素-质量回收率的影响，色谱，2007,23(2):197-202 　　16. Wang Chaozhan,Wang Lili,Geng Xindu,Refolding and purification of recombinant human granulocyte colony-stimulating factor expressed in Escherichia coli using protein folding liquid chromatography.Chinese Journal of Chromatography,2007,25(4):514-517 　　17. 王超展，王骊丽，耿信笃,用蛋白折叠液相色谱法复性和纯化大肠杆菌表达的重组人粒细胞集落刺激因子，色谱，2007,25(4):514-517 　　18. Wu Dan,Wang Chaozhan,Geng Xindu,Effect of mobile phase on the mass recovery of rhIFN-γin protein folding liquid chromatography.Chinese Journal of chromatography,2007,23(2):197-202 　　19. Chaozhan Wang,Lili Wang,Xindu Geng,Renaturation with simultaneous purification of rhG-CSF from Escherichia coli by ion exchange chromatography,Biomedical Chromatography,2007,21(12):1291-1296 　　20. Chaozhan Wang*,Lili Wang,Xindu Geng,High recovery refolding of rhG-CSF from escherichia coli using urea gradient size exclusion chromatography,Biotechnology Progress,2008,24(1):209-213 　　21. Chaozhan Wang*,Jiahua Liu,Lili Wang,Xindu Geng,Solubilization and refolding with simultaneous purification of recombinant human stem cell factor,Applied Biochemistry and Biotechnology,2008,144(2):181-189 　　22. Qinming Zhang,Chaozhan Wang*,Jiang Feng Liu,Li Li Wang,A novel protein refolding method integrating ion exchange chromatography with artificial molecular chaperone,Chinese Chemical Letters,2008,19(5):595-598 　　23.Chaozhan Wang*,Lili Wang,Xindu Geng,Optimization of refolding with simultaneous purification of recombinant human granulocyte colony-stimulating factor from Escherichia coli by immobilized metal ion affinity chraomtography,Biochemical Engineering Journal,2009,43:197-202 　　24. Chaozhan Wang*,Yan Cheng,Urea-gradient Protein Refolding in Size Exclusion Chromatography,Current Pharmaceutical Biotechnology,11(3):289-92(invited review) 　　25. Viivi Majava,Chaozhan Wang,Matti Myllykoski,et al.,Structural analysis of the complex between calmodulin and full-length native myelin basic protein,an intrinsically unstructured molecule,Amino Acids,39(1):59-71(co-first author) 　　26. W.Knoll,F.Natali,J.Peters,Rahul Nanekar,Chaozhan Wang,and P.Kursula,Dynamic properties of areconstituted myelin sheath,Spectroscopy,in press 　　27.Chaozhan Wang*,Qinming Zhang,Yan Cheng,Lili Wang,Refolding of Denatured/Reduced Lysozyme at High Concentrations by Artificial Molecular Chaperone-Ion Exchange Chromatography,Biotechnology Progress,in press 　　28.Suresh S.,Wang Chaozhan,Nanekar R.,Kursula P.&Edwardson J.M.Myelin basic protein and myelin protein 2act synergistically to cause stacking of lipid bilayers.Biochemistry,2010, 49(16):3456-63