【人物简介】

   吴红，第四军医大学药学系化学教研室副主任，教授，博士研究生导师。1988年和1995年分别获得学士与硕士学位，2005年获得博士学位。第四军医大学精品课教员，军队院校育才银奖。2006年获得学校后备人才计划资助,2009年获得学校青年英才支持计划第一层次的资助。担任陕西省生物信息专业委员会委员，西安纳米科技学会理事，国家自然科学基金同行评议专家。

【研究方向】

【研究成果】

负责国家自然科学基金课题3项，全军医药卫生科研基金课题1项，作为副组长承担863专题课题1项，香港CERG课题1项。申请发明专利3项。

【科研项目】

1、微/纳米载药系统。主要开展了新型载体和控释材料的设计与合成、药物与载体的相互作用以及药物载体体系的生物医学性能评价等方面的工作。研制出6种纳米药物载体系统，包括脂质体、纳米微粒、纳米乳剂及纳米凝胶等。发表SCI论文18篇，多篇发表在Biomaterials（IF6.646）、J Control Release (IF5.69)、J Nanopart Res、Int J Pharm等本专业重要期刊上。 2、智能化释药载体。旨在设计位点更具特异性的可控释药体系。该类载体可通过感应病变部位环境信息的变化或依据治疗疾病的需要释放药物，代表了控释制剂的发展方向。目前已有研究的温敏、酸敏体系虽然有较好的智能化可逆响应，但不能降解，限制了其在生物医药领域的应用。因此将可生物降解及智能化响应的微凝胶释药体系作为主攻方向，已制备出智能响应灵敏度高、药物释放可控、可降解的纳米凝胶，有望得到基于多糖酶降解及酸敏响应的新型结肠靶向缓、控释载体。 3、肿瘤靶向纳米药物。在智能药物载体的基础上，筛选出了对肿瘤组织pH值特异响应的纳米载体；进一步与靶向物质结合,旨在构建对肿瘤组织具有特定靶向性和可控释放性的双重靶向给药系统，有望为恶性肿瘤等疾病的药物治疗开辟新途径。

【论文著作】

发表SCI 论文28篇，参编专著2部。副主编“115”国家级规划教材1部。MAJOR PAPERS: 1. Wu H, Zhang ZX, Wu DC, Zhao HP, Yu KT and Hou ZQ. Preparation and drug release characteristics of Pingyangmycin-loaded dextran cross-linked gelatin microspheres for embolization therapy. Journal of Biomedical Materials Research. 2006;78B(1):56-62 2. Wu H, Zhang ZX, Zhao HP, Wu DC, Wu BL and Cong R. Preparation of sodium fluoride-loaded gelatin microspheres, characterization and cariostatic studies. Journal of Microencapsulation. 2004;21(8): 889-903. 3. Fan L, Wu H*, Zhang H, Li F, Yang TH, Gu CH, Yang Q. Novel super pH-sensitive nanoparticles responsive to tumor extracellular pH. Carbohydrate Polymers. 2008;73(3):390-400 4. Fan L, Wu H*, Zhang H, Li F, Yang TH. pH-sensitive Podophyllotoxin carrier for cancer cells specific delivery. Polymer Composites. Early View. DOI 10.1002/ pc.20765 5. Fan L, Wu H*, Zhang H, Li F, Gu CH, Yang Q. Paclitaxel-loaded pH-sensitive nanoparticles targeting tumor extracellular pH. Carbohydrate polymers. 2009;77:773-778 6. Zhang H, Wu H*, Fan L, Li F, Gu CH, Jia M. Preparation and characteristics of pH-Sensitive derivated dextran hydrogel nanoparticles. Polymer Composites. 2008;DOI 10.1002/pc.20684 7. Yi F, Wu H* and Jia GL. Formulation and characterization of poly (D, L-lactide-co-glycolide) nanoparticle containing vascular endothelial growth factor for gene delivery. Journal of Clinical Pharmacy and Therapeutics. 2006;31(1):43-48. 8. Li F, Wu H*, Fan L, Zhang HT. Study of Dual Responsive Dex-MA-graft-PNIPAAm hydrogel nanoparticles: preparation, characterization and biological evaluation. Polymer International. Early view 9. Zhang H, Gu CH, Wu H*, Fan L, Li F, Yang F and Yang Q. Immobilization of derivatized dextran nanoparticles on konjac glucomannan/chitosan film as a novel wound dressing. Biofactors. 2007 (30):227-240. 10. Chunhu Gu, Renhong Zheng, Zhifu Yang, Aidong Wen, Hong Wu*, Hui Zhang and Dinghua Yi*. Novel glycidyl methacrylated dextran/gelatin nanoparticles loaded with basic fibroblast growth factor: formulation and characteristics. rt Drug Development and Industrial Pharmacy (2009) iFirst, 1–11 11. Jin C, Wu H, Liu JY, Bai L, Guo GZ. The effect of paclitaxel-loaded nanoparticles with radiation on hypoxic MCF-7 cells. Journal of Clinical Pharmacy and Therapeutics. 2007;32: 41–47 12. Jin C, Bai L, Wu H, Tian FR, Guo GZ. Radiosensitization of paclitaxel, etanidazole and paclitaxel+etanidazole nanoparticles on hypoxic human tumor cells in vitro. Biomaterials. 2007;28:3724–3730. 13. Chen FM, Zhao YM, Wu H, Deng ZH, Wang QT, Zhou W, Liu Q, Dong GY, Li K, Wu ZF, Jin Y. Enhancement of periodontal tissue regeneration by locally controlled delivery of insulin-like growth factor-I from dextran-co-gelatin microspheres. Journal of Controlled Release. 2006;114(2):209-222. 14. Jin C, Bai L, Wu H, Teng ZH, Guo GZ, Chen JY. Cellular uptake and radiosensitization of SR-2508 loaded PLGA nanoparticles. J Nanopart Res. 2008;10(6):1045-1052 15. Jin C, Bai L, Wu H, Liu JY, Guo GZ, Chen JY. Paclitaxel-loaded poly(D,L-lactide-co-glycolide) nanoparticles for radiotherapy in hypoxic human tumor cells in vitro. Cancer Biology & Therapy 2008;7(4):1-6 16. Fan HB, Hu YY, Qin L, Wu H. Porous gelatin–chondroitin–hyaluronate tri-copolymer scaffold containing microspheres loaded with TGF-β1 induces differentiation of mesenchymal stem cells in vivo for enhancing cartilage repair. Journal of Biomedical Materials Research: Part A. 2006;77(4):785-794 17. Cheng Jin, Ling Bai, Hong Wu, Wenjie Song, Guozhen Guo and Kefeng Dou.Cytotoxicity of Paclitaxel Incorporated in PLGA Nanoparticles on Hypoxic Human Tumor Cells. Pharmaceutical Research. 2009;26(7): DOI: 10.1007/s11095-009-9889-z 18. Chen FM, Wu ZF, Sun HH, Wu H. Release of bioactive BMP from dextran-derives microspheres: A novel delivery concept. Int J Pharm. 2006;307(1):23-32. 19. Hou ZQ, Zhang ZX, Wu H. Effect of Sanguis draxonis (a Chinese traditional herb) on the formation of insulin resistance in rats. Diabetes Research and Clinical Practice. 2005;68(1):3-11. 20. Huang S, Deng T, Wu H, Chen FM and Jin Y. Wound dressings containing bFGF-impregnated microspheres. J Microencapsul. 2006;23(3):277-290. 21. Zhao HP, Wu BL, Wu H. Protective immunity in rats by intranasal immunization with Streptococcus mutans glucan-binding protein D encapsulated into chitosan-coated poly(lactic-co-glycolic acid) microspheres. Biotechnol Lett. 2006;28(16):1299-1304. 22. Wu DC, Wan MX, Wu H. Ultrasonic triggered release drug delivery system of Pluronic micelle. Nanoscience. 2006;11(3):210-218. 23. 参编译著《分子光子学—原理及应用》，科学出版社 24. 参编《Carbohydrate Polymers:Development, Properties and Applications》,Nova 出版社.2009.