【人物简介】

　孙青竹，女，1984年3月生，博士，副教授，硕士生导师。 　　教育经历：2002-2007年，西安交通大学医学部，获医学学士学位；2007-2012年，西安交通大学医学部，获生物学博士学位。 　　工作经历：2012年8月-2016年8月，西安交通大学医学部基础医学院，讲师； 　　2014年9月-2016年10月，瑞士巴塞尔大学，博士后； 　　2016年10月至今，西北农林科技大学动物科技学院，副教授。

【研究方向】

营养元素参与表观遗传调控的机制研究。

【研究成果】

【科研项目】

　西北农林科技大学引进人才启动经费项目，2016.10—2021.10；60万元。在研，项目主持人； 　　国家自然科学基金青年科学基金项目；项目号：31601033；2017.1—2019.12；22万元。在研，项目主持人。 　　陕西省自然科学基础研究计划面上项目；项目号：2015JM8448；2015.1-2016.12；2万元。在研，项目主持人。 　　中国博士后科学基金第52批面上项目；项目号：2012M521754； 2013.1—2014.12；5万元。已结题，项目主持人。 　　西安交通大学基本科研业务费自由探索项目；项目号：DWYXc111000117；2013.1-2015.12；5万元。已结题，项目主持人。 　　西安交通大学“新教师科研支持计划”； 2012.9—2014.12；10万元。已结题，项目主持人。

【论文著作】

　Qingzhu Sun, Li Liu, Daiana Stolz, Michael Tamm, Shemin Lu, Michael Roth* Constitutive high expression of PRMT1 in asthmatic airway smooth muscle cells is caused by reduced MicroRNA-19a and leads to enhanced remodeling.2016Journal of allergy and clinical immunology,IF= 12.485 　　Qingzhu Sun, Li Liu, Daiana Stolz, Michael Tamm, Shemin Lu, Michael Roth* PDGF-BB Induces PRMT1 Expression through ERK1/2 Dependent STAT1 Activation and Regulates Remodeling in Primary Human Lung Fibroblasts. Cellular Signalling 2016 Apr;28(4):307-15. IF= 4.243 　　Li Liu, Qingzhu Sun, Rujuan Bao, Michael Roth, Bo Zhong, Xi Lan, Jia Tian, Qirui He, Dongmin Li, Jian Sun, Xudong Yang, Shemin Lu*. Cell type specific regulation of PRMT1 expression by PIAS1 and RKIP in epithelium and fibroblasts in acute and chronic antigen induced pulmonary inflammation. Scientific Reports - Nature, Accepted, Co-first Author IF= 5.578 　　Qingzhu Sun, Li Liu, Michael Roth, Rujuan Bao, Jia Tian, Qirui He, Xi Lan, Congshan Jiang, Bo Zhong, Jian Sun, Xudong Yang*, Shemin Lu* PRMT1 upregulated by epithelial proinflammatory cytokines participates in COX2 expression in fibroblasts and chronic antigen-induced pulmonary inflammation. The Journal of Immunology 2015 Jul 1;195(1):298-306. IF= 5.264 　　Sun Qingzhu, Yang Xudong, Zhong Bo, Jiao Fangfang, Li Chenyan, Li Dongmin, Lan Xi, Sun Jian, Lu Shemin. Upregulated Protein Arginine Methyltransferase 1 by IL-4 Increases Eotaxin-1 Expression in Airway Epithelial Cells and Participates in Antigen-Induced Pulmonary Inflammation in Rats[J]. The Journal of Immunology, 2012 Apr 1, 188(7):3506-12. IF= 5.264 　　Qingzhu Sun, Xudong Yang, Raza Asim M B, Fangfang Jiao, Shemin Lu. Different challenge terms determine disease patterns of antigen induced pulmonary inflammation in E3 rats [J]. AMPIS, 2011 April/May, 119(4-5), 229–238. IF= 2.042 　　孙青竹，焦芳芳，杨旭东，钟波，蒋梅花，李国良，吕彬，吕社民. PRMTs在E3大鼠哮喘模型中表达变化的研究[J]. 南方医科大学学报，2010. 30(4): 716-719.（Medline收录） 　　Lan X, Yan J, Ren J, Zhong B, Li J, Li Y, Liu L, Yi J, Sun Q, Yang X, Sun J, Meng L, Zhu W, Holmdahl R, Li D, Lu S. A novel long noncoding RNA Lnc-HC binds hnRNPA2B1 to regulate expressions of Cyp7a1 and Abca1 in hepatocytic cholesterol metabolism. Hepatology. 2015 Dec 11. doi: 10.1002/hep.28391. IF= 11.055 　　Jiang C, Yu H, Sun Q, Zhu W, Xu J, Gao N, Zhang R, Liu L, Wu X, Yang X, Meng L, Lu S. Extracellular microRNA-21 and microRNA-26a increase in body fluids from rats with antigen induced pulmonary inflammation and children with recurrent wheezing. BMC Pulm Med. 2016 Apr 14;16:50. doi: 10.1186/s12890-016-0216-2. 　　Jian Sun, Qingzhu Sun, Shemin Lu. From selenoprotein to endochondral ossification: A novel mechanism with microRNAs potential in bone related diseases? [J] Medical Hypotheses. 2011 Nov, 77(5), 807–811. IF="1.389 　　Xudong Yang, Qingzhu Sun, Raza Asim, Xiaogang Jiang, Bo Zhong, Shemin Lu. Nitric oxide both in brochoalveolar lavage fluid and serum is associated with pathogenesis and severity of antigen- induced pulmonary inflammation in rats[J]. Journal of asthma, 2010 Mar, 47(2):135-44. IF="1.372. 　　Zhong B, Yang X, Sun Q, Liu L,Lan X, Tian J, He Q, Hou W, Liu H, Jiang C, Gao N, Lu S. Pdcd4 modulates markers of macrophage alternative activation and airway remodeling in antigen-induced pulmonary inflammation. J Leukoc Biol. 2014 Dec;96(6):1065-75. 　　Katrin E Hostettler, Jun Zhong, Eleni Papakonstantinou, George Karakiulakis, Michael Tamm, Petra Seidel, Qingzhu Sun, Jyotshna Mandal, Didier Lardinois, Christopher Lambers, Michael Roth. Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis. Respiratory Research 2014, 15:157 　　Zixin Min; Wenxiang Zhao; Nannan Zhong; Yuanxu Guo; Qingzhu Sun; Quancheng Wang; Rui Zhang; Jidong Yan; Lifang Tian; Fujun Zhang; Yan Han; Qilan Ning; Liesu Meng; Jian Sun*; Shemin Lu*. Abnormality of epiphyseal plate induced by selenium deficiency diet in two generation DA rats. APMIS. 2015 May 25. doi: 10.1111/apm.12404. 　　Liesu Meng, Xiaojing He, Wenhua Zhu, Xudong Yang, Congshan Jiang, Qingzhu Sun, Asim Raza M.B., Simeng Zhang, Qian Xue, Xinfang Xie, Shemin Lu. TLR3 and TLR7 modulate IgE production in antigen induced pulmonary inflammation via influencing IL-4 expression in immune organs[J]. PLoS ONE. 2011. 6(2): e17252. IF="4.351 　　Dongmin Li, XuanWang, Xi Lan, Yue Li, Li Liu, Jing Yi, Jing Li, Qingzhu Sun, Yili Wang, Hongmin Li, Nannan Zhong, Rikard Holmdahl, Shemin Lu. Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced metabolic syndrome E3 rats. Molecular and Cellular Endocrinology 402 (2015) 1–12 　　Jian Sun, Nannan Zhong, Qibin Li, Zixin Min, Wenxiang Zhao, Qingzhu Sun, Lifang Tian, Hang Yu, Qian Shi, Fujun Zhang, Shemin Lu. MicroRNA of rats articular cartilage at different developmental stages identified by Solexa sequencing [J]. Osteoarthritis and Cartilage. 2011. 19(10):1237-1245. IF="3.953 　　Shahzad M, Yang X, Raza Asim MB, Sun Q, Han Y, Zhang F, Cao Y, Lu S. Black seed oil ameliorates allergic airway inflammation by inhibiting T-cell proliferation in rats. Pulm Pharmacol Ther[J]. 2009; 22(1):37-43. IF= 2.09 　　Raza Asim M B, Xudong Yang, Muhammad Shahzad, Qingzhu Sun, Fujun Zhang, Yan Han and Shemin Lu. Role of arginase pathway in lung remodeling through the downstream products in antigen induced pulmonary inflammation of E3 rats[J]. Swiss Medical Weekly, 2010; 140:w13128. IF= 1.82 　　李晨燕，孙青竹，杨旭东，钟波，韩燕，吕社民。人PRMT1基因真核载体的构建与鉴定[J]. 细胞与分子免疫学杂志，2012.28(4): 384-7. (Medline收录) 　　韩燕; 张欢; 宁启兰; 钟波; 孙青竹; 温玉荣; 高成阁; 马捷. 中国汉族女性中G72 基因与精神分裂症的关系[J]. 第二军医大学学报，2010.31(8): 826-829. (核心期刊)