【人物简介】

　　常颖，教授，博士，曾在法国巴斯德研究所与加拿大麦吉尔大学做博士后研究工作，现任西安交通大学前沿科学技术研究院前沿院转化医学研究中心研究小组主任。

【研究方向】

角色的微型车慢性炎症性肺疾病的发病机理

【研究成果】

【科研项目】

【论文著作】

　　1. Y Chang, L Al-Alwan, S Audusseau, F Chouiali, J Carlevaro-Fita, Y Iwakura, CJ Baglole, D H Eidelman, Q Hamid. Genetic deletion of IL-17A reduces cigarette smoke-induced inflammation and alveolar type II cell apoptosis. AJP Lung Cellular and Molecular Physiology, 2014, 306（2）：L132-43. 　　2. Y Chang （Co-first author）， L Al-Alwan, , A Mogas, A J Halayko, C J Baglole, J G Martin, D H Eidelman, Q Hamid. Differential roles of CXCL2 and CXCL3 and their receptors in regulating normal and asthmatic airway smooth muscle cell migration. J Immunol, 2013, 191（5）：2731-41. 　　3. Y Chang, L Al-Alwan, PA Risse, A J Halayko, J G Martin, C J Baglole, D H Eidelman, Q Hamid. Th17 Associated Cytokines Promote Human Airway Smooth Muscle Cell Proliferation. FASEB J. 2012, 26（12）：5152-60. 　　4. Y Chang （Co-first author）， L Al-Alwan, C J Baglole, PA Risse, A J Halayko, J G Martin, D H Eidelman, Q Hamid. Autocrine-regulated airway smooth muscle cell migration is dependent on IL-17-induced growth-related oncogenes. J Allergy Clin Immunol, 2012, 130（4）：977-985. 　　5. Chang Y （Co-first author）， Chenivesse C, Azzaoui I, Ait Yahia S, Morales O, Plé C, Foussat A, Tonnel AB, Delhem N, Yssel H, Vorng H, Wallaert B, Tsicopoulos A. Pulmonary CCL18 recruits human regulatory T cells. J Immunol, 2012, 189（1）：128-37. 　　6. Y Chang, L Al-Alwan, PA Risse, L Roussel, S Rousseau, A J Halayko, J G. Martin, Q Hamid, D H Eidelman. Th17 cytokines induce human airway smooth muscle cell migration. J Allergy Clin Immunol, 2011, 127（4）：1046-53. 　　7. Y Chang, J Nadigel, N Boulais, J Boubeau, F Maltais, D H Eidelman, Q Hamid. CD8 positive T cells are a major source of IL-17 in patients with Chronic Obstructive Pulmonary Disease. Respir Res. 2011,12: 43. 　　8. I Azzaoui, S A Yahia, Y Chang, H Vorng, O Morales, Y Fan, N Delhem, C Ple, AB Tonnel , B Wallaert, and A Tsicopoulos. CCL18 differentiates dendritic cells in tolerogenic cells able to prime regulatory T cells in healthy but not allergic subjects. Blood, 2011, 118（13）：3549-58. 　　9. Chang Y, de Nadai P, Azzaoui I, Morales O, Delhem N, Vorng H, Tomavo S, Ait Yahia S, Zhang G, Wallaert B, Chenivesse C, Tsicopoulos A. The chemokine CCL18 generates adaptive regulatory T cells from memory CD4+ T cells of healthy but not allergic subjects. FASEB J, 2010, 24（12）：5063-72. 　　10. Y Chang, GZ Zhang, SL Piao, S Gao, DM Zheng, Y Song, A Tsicopoulos, S Ying. Protective effects of combined micronutrients on islet b cells of streptozotocin-induced diabetic mice. Int J Vitam Nutr Res. 2009, 79（2）：104-16. 　　11. Chang Y （Co-first author）， Gilet J, Chenivesse C, Legendre B, Vorng H, Duez C, Wallaert B, Porte H, Senechal S, Tsicopoulos A. Role of CCL17 in the generation of cutaneous inflammatory reactions in Hu-PBMC-SCID mice grafted with human skin. J Invest Dermatol. 2009, 129（4）： 879-90. 　　12. Chang Y, Senechal S, de Nadai P, Chenivesse C, Gilet J, Vorng H, Legendre B, Tonnel AB, Wallaert B, Lassalle P, Tsicopoulos A. Diesel exhaust exposure favors TH2 cell recruitment in nonatopic subjects by differentially regulating chemokine production. J Allergy Clin Immunol, 2006, 118（2）： 354-60.