【人物简介】

　　王志鹏，男，第四军医大学药学院药理学教研室副教授，硕士生导师。中国药理学会会员和欧洲癌症研究学会会员。陕西省药品不良反应监测委员会专家。主要从事肿瘤药理学研究工作。

【研究方向】

肿瘤药理学研究。

【研究成果】

　　申请发明专利2项。

【科研项目】

　　负责国家自然科学基金课题2项，陕西省科技公关课题1项，2010年获得第四军医大学优秀留学回国人员启动基金（第2层次）资助。参与国家自然科学基金、973前期研究专项、陕西省13115科技创新项目等共6项。

【论文著作】

　　1.Wang Z, Liu L, Wang M, Shen M, Li J, Liu J, Li C, Xin C, Zhu S, Mei Q, Wang Y. NOTCH1 regulates migration and invasion of skin cancer cells by E-cadherin repression. Mol Cell Biochem. 2011 Oct 29. [Epub ahead of print] 　　2. Wang Z, Pedersen E, Basse A, Lefever T, Karine P, Kapoor S, Mei Q, Karlsson R, Brakebusch C.Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo. Oncogene, 2010, 29:3362-73 　　3. Wang Z, Liang B, Mei Q. Routine early angioplasty after fibrinolysis. N Engl J Med. 2009, 361:1509 　　4. Wang Z, Jin H, Xu R, Mei Q, Fan D. Triptolide inhibits proliferation and migration, enhance apoptosis in inflammatory bowel diseases induced colorectal cancer via Rac1/JAK/STAT3 pathway. Exp mol med 2009 31;41:717-27. 　　5. Wang Z, Jin H, Li C, Hou Y, Mei Q, Fan D. Heat shock protein 72 protects kidney proximal tubule cells from injury induced by triptolide by means of activation of the MEK/ERK pathway. Int J toxicol 2009, 28:177-89 　　6. Wang Z, Mingkai L, Shuyu C, Min J, Jingru M, Xue M, Yuemei W, Xiaoxing L. Toxicity of Coenzyme Q10: A report of 90-day repeated dose toxicity study in rats. J Toxicol Sci. 2007;32（5）：505-14. 　　7. Wang Z, Li L, Qibing M, Linna L, Yuhua R, Rong Z . Increased expression of heat shock protein （HSP）72 in a human proximal tubular cell line （HK-2） with gentamicin-induced injury. J Toxicol Sci. 2006; 31: 61-70 　　8. Wang Z, Liu L, Mei Q, Liu L, Ran Y, Zhang R . Increased expression of heat shock protein 72 protects renal proximal tubular cells from gentamicin-induced injury. J Korean Med Sci. 2006; 21:904-10 　　9. Jin H, Wang Z*, Fan D.R-flurbiprofen reverses multidrug resistance, proliferation and metastasis in gastric cancer cells by p75NTR induction. Mol Pharm. 2010 ;7:156-68（co-first author） 　　10. Wen A, Wang Z, Hang T, Jia Y, Zhang T, Wu Y, Gao X, Yang Z （2007）。 Analysis of sofalcone in human plasma by high performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;856:348-52. 　　11. Du D, Pedersen E, Wang Z, Karlsson R, Chen Z, Wu X, Brakebusch C. Cdc42 is crucial for the maturation of primordial cell junctions in keratinocytes independent of Rac1. Exp Cell Res, 2009, 815: 1480-1489 　　12. Richard K, Esben P, Wang Z, Cord B. RhoGTPases function in tumor. BBA Cancer 2009, 1796: 91-8 　　13.Jackson B, Peyrollier K, Pedersen E, Basse A, Karlsson R, Wang Z, Lefever T, Ochsenbein AM, Schmidt G, Aktories K, Stanley A, Quondamatteo F, Ladwein M, Rottner K, van Hengel J, Brakebusch C. RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes. Mol Biol Cell. 2011; 22: 593-605.